ea0038p369 | Reproduction | SFEBES2015
Jarvis Sheba
, Gadaleta Raffaela M
, Want Elizabeth J
, Gray Nicola
, Abu-Hayyeh Shadi
, Winston Lord Robert
, Williamson Catherine
, Bevan Charlotte L
Background: Bile acids (BAs) are end-products of cholesterol catabolism, which act as signalling molecules to regulate glucose, lipid and energy metabolism. BAs activate several receptors including the ligand sensitive transcription factor Farnesoid X receptor (FXR) and the membrane G-protein coupled receptor, TGR5. Besides the organs physiologically in contact with BAs, like the gut and liver, BA-receptors are also expressed in cholesterol-rich steroidogenic tissues, such as ...